https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Disparities in the incidence of acute myocardial infarction: long-term trends from the Hunter region https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32642 Wed 24 Nov 2021 15:52:35 AEDT ]]> The tetraspanin CD151’s role in the kidney and mapping of genetic modifiers of glomerular disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21095 Wed 11 Apr 2018 09:42:34 AEST ]]> Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50715 Wed 02 Aug 2023 16:17:49 AEST ]]> Characterization of the early molecular changes in the glomeruli of Cd151-/- mice highlights induction of mindin and MMP-10 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33471 -/- mice compared to Cd151+/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151-/- compared to Cd151+/+ glomeruli (p<0.05). Further analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix protein mindin (encoded by Spon2) in the diseased FVB/N Cd151-/- GBM that did not occur in the C57BL/6 diseased-resistant strain. Interestingly, mindin was also detected in urinary samples of FVB/N Cd151-/- mice, underlining its potential value as a biomarker for glomerular diseases associated with GBM alterations. Gene set enrichment and pathway analysis of the microarray dataset showed enrichment in axon guidance and actin cytoskeleton signalling pathways as well as activation of inflammatory pathways. Given the known function of mindin, its early expression in the diseased GBM could represent a trigger of both further podocyte cytoskeletal changes and inflammation, thereby playing a key role in the mechanisms of disease progression.]]> Tue 03 Sep 2019 18:26:44 AEST ]]> Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34229 proportional reduction in CSA in young and aging mice. This produced the same pressure gradient across the constriction and the same rise in B-type natriuretic peptide expression. Young mice showed acute deterioration in systolic function assessed by pressure-volume loops, progressive LV remodeling on echocardiography, and a 50% mortality at 12 weeks post-TAC. In contrast, aging mice showed no acute deterioration in systolic function, much less ventricular remodeling and were protected from death. Aging mice also showed significantly increased levels of matrix metalloproteinase-3 (MMP-3; 3.2 fold increase, P<0.001) and MMP-12 (1.5-fold increase, P<0.001), which were not seen in young mice. Expression of tissue inhibitor of MMP-1 (TIMP-1) increased 8.6-fold in aging hearts vs 4.3-fold in young hearts (P<0.01). In conclusion, following size-appropriate TAC, aging mice exhibit less LV remodeling and lower mortality than young adult mice. This is associated with induction of protective ECM changes.]]> Tue 03 Sep 2019 18:22:57 AEST ]]> Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33473 Thu 09 Dec 2021 11:01:36 AEDT ]]> miR-518f-5p decreases tetraspanin CD9 protein levels and differentially affects non-tumourigenic prostate and prostate cancer cell migration and adhesion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33474 Thu 03 Feb 2022 12:18:02 AEDT ]]> Trends in the incidence of first acute myocardial infarction in metropolitan and regional areas of the Hunter Region https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41893 Mon 15 Aug 2022 12:02:34 AEST ]]> Tetraspanin CD9 is regulated by MiR-518f-5p and functions in breast cell migration and in vivo tumor growth https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44184 Mon 10 Oct 2022 10:48:32 AEDT ]]>